Cell Assemblies of the Basal Forebrain

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Cell assemblies of the basal forebrain.

The basal forebrain comprises several heterogeneous neuronal subgroupings having modular projection patterns to discrete sets of cortical subregions. Each cortical region forms recurrent projections, via prefrontal cortex, that reach the specific basal forebrain subgroups from which they receive afferents. This architecture enables the basal forebrain to selectively modulate cortical responsive...

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The basal forebrain (BF) consists of a heterogeneous population of cholinergic, GABAergic, and glutamatergic neurons having projections to most cortical regions. The importance of these projections for cognitive processing has been demonstrated in behavioral studies employing lesions of BF and in examining impairments in cognitive processing in patient populations (e.g., Alzheimers disease). In...

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Following injections of wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) or the fluorescent tracer fluoro-gold into the magnocellular preoptic area and the horizontal limb of the diagonal band, retrogradely labelled neurons were found in the homotopic region of the contralateral basal forebrain. Labelled fibers apparently arising from these neurons travelled in the stria medull...

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ژورنال

عنوان ژورنال: Journal of Neuroscience

سال: 2015

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.4432-14.2015